› 6j1n

X-ray diffraction
2.53Å resolution

Anisodus acutangulus type III polyketide sythase AaPKS2 in complex with 4-carboxy-3-oxobutanoyl-CoA

Released:
DOI: 10.2210/pdb6j1n/pdb
PDB 6j1n coloured by chain and viewed from the front.
PDB 6j1n coloured by chain and viewed from the side.
PDB 6j1n coloured by chain and viewed from the top.
Source organism: Anisodus acutangulus
Primary publication:
Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation.
Huang JP, Fang C, Ma X, Wang L, Yang J, Luo J, Yan Y, Zhang Y, Huang SX
OpenAccess logo Nat Commun 10 4036 (2019)
PMID: 31492848

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A. acutangulus PKS2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 427 amino acids
Theoretical weight: 46.73 KDa
Source organism: Anisodus acutangulus
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand B7X 2 x B7X
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P3221
Unit cell:
a: 108.347Å b: 108.347Å c: 191.485Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.166 0.191
Expression system: Escherichia coli

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Citations

1 review citation

Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases.
Abe I. (2020)
1 other article

1 mention without citation

Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation.
Huang et al. (2019)