X-ray diffraction
1.88Å resolution

Crystal structure of activated c-KIT in complex with compound

Source organism: Homo sapiens
Entry authors: Wu TS, Wu SY

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.75 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
  • Canonical: P10721 (Residues: 547-693, 754-935; Coverage: 35%)
  • Best match: P10721-4 (Residues: 27-32, 35-216)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL15A1
Spacegroup: P43212
Unit cell:
a: 59.853Å b: 59.853Å c: 197.984Å
α: 90° β: 90° γ: 90°
R R work R free
0.183 0.18 0.231
Expression system: unidentified baculovirus