X-ray diffraction
2.81Å resolution

Complex structure of INADL PDZ89 and PLCb4 C-terminal CC-PBM

Source organisms:
Entry authors: Ye F, Li J, Huang Y, Liu W, Zhang M

Function and Biology Details

Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase Chain: B
Molecule details ›
Chain: B
Length: 266 amino acids
Theoretical weight: 31.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q91UZ1 (Residues: 912-1175; Coverage: 23%)
Gene name: Plcb4
InaD-like protein Chain: C
Molecule details ›
Chain: C
Length: 216 amino acids
Theoretical weight: 22.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8NI35 (Residues: 1421-1625; Coverage: 11%)
Gene names: CIPP, INADL, PATJ
Sequence domains: PDZ domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P3121
Unit cell:
a: 69.089Å b: 69.089Å c: 200.375Å
α: 90° β: 90° γ: 120°
R R work R free
0.247 0.244 0.302
Expression system: Escherichia coli BL21(DE3)