X-ray diffraction
1.78Å resolution

Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15


Function and Biology Details

Reaction catalysed:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
UDP-glucuronosyltransferase 2B15 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 191 amino acids
Theoretical weight: 21.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P54855 (Residues: 284-451; Coverage: 33%)
Gene names: UGT2B15, UGT2B8
Sequence domains: UDP-glucoronosyl and UDP-glucosyl transferase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 50.067Å b: 141.824Å c: 56.884Å
α: 90° β: 115.58° γ: 90°
R R work R free
0.147 0.146 0.18
Expression system: Escherichia coli BL21(DE3)