X-ray diffraction
2.89Å resolution

Crystal structures of the hMTR4-NRDE2 complex


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Exosome RNA helicase MTR4 Chain: B
Molecule details ›
Chain: B
Length: 979 amino acids
Theoretical weight: 111.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P42285 (Residues: 71-1042; Coverage: 93%)
Gene names: DOB1, KIAA0052, MTR4, MTREX, SKIV2L2
Sequence domains:
Nuclear exosome regulator NRDE2 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9H7Z3 (Residues: 163-266; Coverage: 9%)
Gene names: C14orf102, NRDE2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 148.305Å b: 113.728Å c: 80.717Å
α: 90° β: 96.49° γ: 90°
R R work R free
0.236 0.236 0.252
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli