› 6icx

X-ray diffraction
2.4Å resolution

Crystal structure of H7 hemagglutinin mutant AH-AGPL (V186G) from the influenza virus A/Anhui/1/2013 (H7N9)

Released:
DOI: 10.2210/pdb6icx/pdb
PDB 6icx coloured by chain and viewed from the front.
PDB 6icx coloured by chain and viewed from the side.
PDB 6icx coloured by chain and viewed from the top.
Source organism: Influenza A virus
Primary publication:
Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin.
Xu Y, Peng R, Zhang W, Qi J, Song H, Liu S, Wang H, Wang M, Xiao H, Fu L, Fan Z, Bi Y, Yan J, Shi Y, Gao GF
Cell Rep 29 2217-2228.e5 (2019)
PMID: 31747596

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 34.95 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: R4NN21 (Residues: 19-339; Coverage: 57%)
Gene name: HA
Sequence domains: Haemagglutinin
Hemagglutinin Chain: B
Molecule details ›
Chain: B
Length: 177 amino acids
Theoretical weight: 20.44 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: R4NN21 (Residues: 340-516; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: R32
Unit cell:
a: 115.318Å b: 115.318Å c: 293.318Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.268 0.266 0.3
Expression system: Spodoptera frugiperda

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Citations

5 review citations

Adaptation of influenza viruses to human airway receptors.
Thompson et al. (2021)
4 more