› 6icx

X-ray diffraction
2.4Å resolution

Crystal structure of H7 hemagglutinin mutant AH-AGPL (V186G) from the influenza virus A/Anhui/1/2013 (H7N9)

Released:
DOI: 10.2210/pdb6icx/pdb
PDB entry 6icx coloured by chain, front view.
PDB entry 6icx coloured by chain, side view.
PDB entry 6icx coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin.
Xu Y, Peng R, Zhang W, Qi J, Song H, Liu S, Wang H, Wang M, Xiao H, Fu L, Fan Z, Bi Y, Yan J, Shi Y, Gao GF
Cell Rep 29 2217-2228.e5 (2019)
PMID: 31747596

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195776 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 34.95 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: R4NN21 (Residues: 19-339; Coverage: 57%)
Gene name: HA
Sequence domains: Haemagglutinin
Hemagglutinin Chain: B
Molecule details ›
Chain: B
Length: 177 amino acids
Theoretical weight: 20.44 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: R4NN21 (Residues: 340-516; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: R32
Unit cell:
a: 115.318Å b: 115.318Å c: 293.318Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.268 0.266 0.3
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Adaptation of influenza viruses to human airway receptors.
Thompson et al. (2021)
7 more