› 6i81

X-ray diffraction
1.74Å resolution

Crystal Structure of the second bromodomain of BRD2 in complex with RT56

Released:
DOI: 10.2210/pdb6i81/pdb
PDB 6i81 coloured by chain and viewed from the front.
PDB 6i81 coloured by chain and viewed from the side.
PDB 6i81 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Picaud S, Traquete R, Bernardes GJL, Newman J, Arrowsmith CH, Edwards AM, Bountra C, Filippakopoulos P, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25440 (Residues: 348-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
Ligand MES 1 x MES
Ligand EDO 1 x EDO
Ligand H7E 1 x H7E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: I4122
Unit cell:
a: 127.297Å b: 127.297Å c: 40.594Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.196
Expression system: Escherichia coli BL21(DE3)

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