6i81

X-ray diffraction
1.74Å resolution

Crystal Structure of the second bromodomain of BRD2 in complex with RT56

Released:
Source organism: Homo sapiens
Entry authors: Picaud S, Traquete R, Bernardes GJL, Newman J, Arrowsmith CH, Edwards AM, Bountra C, Filippakopoulos P, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25440 (Residues: 348-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: I4122
Unit cell:
a: 127.297Å b: 127.297Å c: 40.594Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.196
Expression system: Escherichia coli BL21(DE3)