6i7s

X-ray diffraction
2.5Å resolution

Microsomal triglyceride transfer protein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein disulfide-isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 492 amino acids
Theoretical weight: 55.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P07237 (Residues: 18-508; Coverage: 100%)
Gene names: ERBA2L, P4HB, PDI, PDIA1, PO4DB
Sequence domains:
Microsomal triglyceride transfer protein large subunit Chains: G, H
Molecule details ›
Chains: G, H
Length: 884 amino acids
Theoretical weight: 98.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P55157 (Residues: 1-1, 19-894; Coverage: 98%)
Gene names: MTP, MTTP
Sequence domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P1
Unit cell:
a: 77.537Å b: 105.595Å c: 112.269Å
α: 89.81° β: 76.95° γ: 74.24°
R-values:
R R work R free
0.207 0.204 0.257
Expression system: Escherichia coli K-12