6i7a

X-ray diffraction
2.2Å resolution

Co-crystal structure of human SPOP MATH domain (D140N) and human BRD3 fragment

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-129127 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Speckle-type POZ protein Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 145 amino acids
Theoretical weight: 16.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43791 (Residues: 28-166; Coverage: 37%)
Gene name: SPOP
Sequence domains: MATH domain
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Bromodomain-containing protein 3 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 9 amino acids
Theoretical weight: 936 Da
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15059 (Residues: 245-253; Coverage: 1%)
Gene names: BRD3, KIAA0043, RING3L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P41212
Unit cell:
a: 90.351Å b: 90.351Å c: 166.591Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.234
Expression system: Escherichia coli BL21(DE3)