› 6i65

X-ray diffraction
1.5Å resolution

Crystal structure of human ERRg LBD in complex with 4-iso-propylphenol

Released:
DOI: 10.2210/pdb6i65/pdb
PDB 6i65 coloured by chain and viewed from the front.
PDB 6i65 coloured by chain and viewed from the side.
PDB 6i65 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors.
Thouennon E, Delfosse V, Bailly R, Blanc P, Boulahtouf A, Grimaldi M, Barducci A, Bourguet W, Balaguer P
Cell Mol Life Sci 76 4769-4781 (2019)
PMID: 31127318

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62508 (Residues: 222-458; Coverage: 52%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand H3Z 1 x H3Z
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P41212
Unit cell:
a: 64.434Å b: 64.434Å c: 137.275Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.198
Expression system: Escherichia coli

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Citations

1 review citation

Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis.
Tang et al. (2021)
1 other article