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Crystal structure of SOCS2:Elongin C:Elongin B in complex with erythropoietin receptor peptide

X-ray diffraction
2.69Å resolution
PDB entry 6i4x coloured by chain, front view.
PDB entry 6i4x coloured by chain, side view.
PDB entry 6i4x coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 16835.34 Å2
Buried surface area: 6134.93 Å2
Dissociation area: 544.78 Å2
Dissociation energy (ΔGdiss): 9.35 kcal/mol
Dissociation entropy (TΔSdiss): 7.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126987

Macromolecules

Elongin-B
Chain: B
Length: 104 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15370 (Residues: 1-104; Coverage: 88%)
Gene names: ELOB, TCEB2
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Elongin-B in PDB entry 6i4x, assembly 1, front view.
Elongin-B in PDB entry 6i4x, assembly 1, side view.
Elongin-B in PDB entry 6i4x, assembly 1, top view.
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Elongin-C
Chain: C
Length: 97 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15369 (Residues: 17-112; Coverage: 86%)
Gene names: ELOC, TCEB1
Pfam: Skp1 family, tetramerisation domain
InterPro:
CATH: Potassium Channel Kv1.1; Chain A
Elongin-C in PDB entry 6i4x, assembly 1, front view.
Elongin-C in PDB entry 6i4x, assembly 1, side view.
Elongin-C in PDB entry 6i4x, assembly 1, top view.
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Suppressor of cytokine signaling 2
Chain: A
Length: 169 amino acids
Theoretical weight: 19.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14508 (Residues: 30-198; Coverage: 85%)
Gene names: CIS2, SOCS2, SSI2, STATI2
Pfam:
InterPro:
CATH: SOCS box
Suppressor of cytokine signaling 2 in PDB entry 6i4x, assembly 1, front view.
Suppressor of cytokine signaling 2 in PDB entry 6i4x, assembly 1, side view.
Suppressor of cytokine signaling 2 in PDB entry 6i4x, assembly 1, top view.
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Erythropoietin receptor
Chain: D
Length: 11 amino acids
Theoretical weight: 1.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
Erythropoietin receptor in PDB entry 6i4x, assembly 1, front view.
Erythropoietin receptor in PDB entry 6i4x, assembly 1, side view.
Erythropoietin receptor in PDB entry 6i4x, assembly 1, top view.
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