X-ray diffraction
1.78Å resolution

Alpha-1-antitrypsin Queen's (K154N) variant

Source organism: Homo sapiens
Entry authors: Aldobiyan I, Lomas DA, Irving JA

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 404 amino acids
Theoretical weight: 45.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
  • Canonical: P01009 (Residues: 26-418; Coverage: 100%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 114.46Å b: 38.95Å c: 89.85Å
α: 90° β: 103.95° γ: 90°
R R work R free
0.185 0.183 0.213
Expression system: Escherichia coli K-12