6i3u

X-ray diffraction
2.09Å resolution

Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase catalytic subunit type 3 Chain: A
Molecule details ›
Chain: A
Length: 615 amino acids
Theoretical weight: 70.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NEB9 (Residues: 268-686, 687-879; Coverage: 69%)
Gene names: PIK3C3, VPS34
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 84.17Å b: 167.17Å c: 61.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.236
Expression system: Escherichia coli