› 6i10

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172542 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fascin Chain: A
Molecule details ›
Chain: A
Length: 493 amino acids
Theoretical weight: 54.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16658 (Residues: 1-493; Coverage: 100%)
Gene names: FAN1, FSCN1, HSN, SNL
Sequence domains: Fascin domain
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

3 bound ligands:
Ligand GZK 1 x GZK
Ligand ACT 1 x ACT
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 61.667Å b: 91.839Å c: 97.062Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.25 0.287
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

How does fascin promote cancer metastasis?
Lin et al. (2021)
4 more

2 mentions without citation

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Francis et al. (2019)
1 more