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Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors.

Coyle T, Wu L, Debowski AW, Davies GJ, Stubbs KA
Chembiochem 20 1365-1368 (2019)
Cited: 4 times
EuropePMC logo PMID: 30663832

Abstract

The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α-l-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α-l-fucosidase inhibitors, with X-ray crystallographic analysis using an α-l-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.

Articles - 6hzy mentioned but not cited (2)

  1. Origins and Evolution of the α-L-Fucosidases: From Bacteria to Metazoans. You J, Lin S, Jiang T. Front Microbiol 10 1756 (2019)
  2. Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors. Coyle T, Wu L, Debowski AW, Davies GJ, Stubbs KA. Chembiochem 20 1365-1368 (2019)


Reviews citing this publication (1)

  1. The dual role of fucosidases: tool or target. Jiménez-Pérez C, Guzmán-Rodríguez F, Cruz-Guerrero AE, Alatorre-Santamaría S. Biologia (Bratisl) 1-16 (2023)

Articles citing this publication (1)

  1. Discovery of α-l-Glucosidase Raises the Possibility of α-l-Glucosides in Nature. Shishiuchi R, Kang H, Tagami T, Ueda Y, Lang W, Kimura A, Okuyama M. ACS Omega 7 47411-47423 (2022)


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