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Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A resolution in complex with inosine

X-ray diffraction
1.399Å resolution
PDB entry 6hyi coloured by chain, front view.
PDB entry 6hyi coloured by chain, side view.
PDB entry 6hyi coloured by chain, top view.
Source organism: Trypanosoma cruzi
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclic nucleotide-binding domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 14253.92 Å2
Buried surface area: 1072.25 Å2
Dissociation area: 266.56 Å2
Dissociation energy (ΔGdiss): -1.71 kcal/mol
Dissociation entropy (TΔSdiss): 3.75 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-183143

Macromolecules

Cyclic nucleotide-binding domain-containing protein
Chain: B
Length: 304 amino acids
Theoretical weight: 34.48 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q86RB0 (Residues: 200-503; Coverage: 60%)
Gene names: C3747_37g237, ECC02_004294, PKAR
Pfam: Cyclic nucleotide-binding domain
InterPro:
Cyclic nucleotide-binding domain-containing protein in PDB entry 6hyi, assembly 1, front view.
Cyclic nucleotide-binding domain-containing protein in PDB entry 6hyi, assembly 1, side view.
Cyclic nucleotide-binding domain-containing protein in PDB entry 6hyi, assembly 1, top view.
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