PDBe 6hyc

X-ray diffraction
3.18Å resolution

The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phenylalanine-4-hydroxylase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 452 amino acids
Theoretical weight: 51.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
  • Canonical: P00439 (Residues: 1-452; Coverage: 100%)
Gene name: PAH
Sequence domains:

Ligands and Environments


Cofactor: Ligand H4B 3 x H4B
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: C2
Unit cell:
a: 101.94Å b: 101.368Å c: 203.543Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.262 0.311
Expression system: Escherichia coli #1/H766