› 6hxn

X-ray diffraction
1.7Å resolution

Structure of the citryl-CoA lyase core module of Chlorobium limicola ATP citrate lyase (space group P3121)

Released:
DOI: 10.2210/pdb6hxn/pdb
PDB 6hxn coloured by chain and viewed from the front.
PDB 6hxn coloured by chain and viewed from the side.
PDB 6hxn coloured by chain and viewed from the top.
Source organism: Chlorobium limicola
Primary publication:
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K
Nature 568 571-575 (2019)
PMID: 30944476

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CoA_binding domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 279 amino acids
Theoretical weight: 30.76 KDa
Source organism: Chlorobium limicola
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9AJC4 (Residues: 351-608; Coverage: 42%)
Gene name: aclA
Sequence domains: Citrate synthase, C-terminal domain

Ligands and Environments

2 bound ligands:
Ligand COA 2 x COA
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P3121
Unit cell:
a: 110.029Å b: 110.029Å c: 92.749Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.173 0.192
Expression system: Escherichia coli BL21

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Citations

8 review citations

Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.
Gowda et al. (2022)
7 more