› 6hnv

X-ray diffraction
2.6Å resolution

Crystal structure of aminotransferase Aro9 from C. Albicans with ligands

Released:
DOI: 10.2210/pdb6hnv/pdb
PDB entry 6hnv coloured by chain, front view.
PDB entry 6hnv coloured by chain, side view.
PDB entry 6hnv coloured by chain, top view.
Source organism: Candida albicans
Primary publication:
Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties.
Kiliszek A, Rypniewski W, Rząd K, Milewski S, Gabriel I
J Struct Biol 205 26-33 (2019)
PMID: 30742897

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aminotransferase class I/classII domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 524 amino acids
Theoretical weight: 59.02 KDa
Source organism: Candida albicans
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: A0A1D8PMC5 (Residues: 1-523; Coverage: 100%)
Gene names: ARO9, CAALFM_C405560CA, orf19.8822
Sequence domains: Aminotransferase class I and II

Ligands and Environments

7 bound ligands:
Ligand PLP 2 x PLP
Ligand BCN 3 x BCN
Ligand MPD 1 x MPD
Ligand PHE 1 x PHE
Ligand PPY 1 x PPY
Ligand UN1 1 x UN1
Ligand OOG 1 x OOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 74.57Å b: 88.54Å c: 160.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.28
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

1 review citation

Protein-Protein Interactions in Candida albicans.
Schoeters et al. (2019)
3 other articles