› 6hn6

X-ray diffraction
2.71Å resolution

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor RXR-ALPHA

Released:
DOI: 10.2210/pdb6hn6/pdb
PDB 6hn6 coloured by chain and viewed from the front.
PDB 6hn6 coloured by chain and viewed from the side.
PDB 6hn6 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor α.
Eberhardt J, McEwen AG, Bourguet W, Moras D, Dejaegere A
Acta Crystallogr F Struct Biol Commun 75 98-104 (2019)
PMID: 30713160

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 282 amino acids
Theoretical weight: 31.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 201-462; Coverage: 57%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand CPS 4 x CPS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: P6322
Unit cell:
a: 110.8Å b: 110.8Å c: 109.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.173 0.231
Expression system: Escherichia coli BL21(DE3)

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Citations

2 citation in other articles

A molecular switch regulating transcriptional repression and activation of PPARγ.
Shang et al. (2020)
1 more