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Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide

X-ray diffraction
2.194Å resolution
PDB entry 6hks coloured by chain, front view.
PDB entry 6hks coloured by chain, side view.
PDB entry 6hks coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 3 and Protein E6
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Multimeric state: hetero dimer
Accessible surface area: 5955.77 Å2
Buried surface area: 1219.14 Å2
Dissociation area: 540.53 Å2
Dissociation energy (ΔGdiss): 0.97 kcal/mol
Dissociation entropy (TΔSdiss): 6.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136589
Assembly 2
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 3 and Protein E6
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Multimeric state: hetero dimer
Accessible surface area: 5968.08 Å2
Buried surface area: 1132.33 Å2
Dissociation area: 498.55 Å2
Dissociation energy (ΔGdiss): 0.23 kcal/mol
Dissociation entropy (TΔSdiss): 6.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136589
Assembly 3
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 3 and Protein E6
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Multimeric state: hetero dimer
Accessible surface area: 5678.58 Å2
Buried surface area: 1127.66 Å2
Dissociation area: 495.1 Å2
Dissociation energy (ΔGdiss): 0.63 kcal/mol
Dissociation entropy (TΔSdiss): 6.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136589
Assembly 4
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 3 and Protein E6
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Multimeric state: hetero dimer
Accessible surface area: 5928.69 Å2
Buried surface area: 973.86 Å2
Dissociation area: 486.93 Å2
Dissociation energy (ΔGdiss): 0.55 kcal/mol
Dissociation entropy (TΔSdiss): 6.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136589
Assembly 5
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 3 and Protein E6
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Multimeric state: hetero dimer
Accessible surface area: 6007.64 Å2
Buried surface area: 1115.44 Å2
Dissociation area: 489.52 Å2
Dissociation energy (ΔGdiss): 0.6 kcal/mol
Dissociation entropy (TΔSdiss): 6.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136589
Assembly 6
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 3 and Protein E6
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Multimeric state: hetero dimer
Accessible surface area: 6009.58 Å2
Buried surface area: 1386.71 Å2
Dissociation area: 553.4 Å2
Dissociation energy (ΔGdiss): 0.9 kcal/mol
Dissociation entropy (TΔSdiss): 6.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136589

Macromolecules

Tyrosine-protein phosphatase non-receptor type 3
Chains: A, B, C, D, E, F
Length: 114 amino acids
Theoretical weight: 12.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26045 (Residues: 489-597; Coverage: 12%)
Gene names: PTPH1, PTPN3
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
Tyrosine-protein phosphatase non-receptor type 3 in PDB entry 6hks, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 3 in PDB entry 6hks, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 3 in PDB entry 6hks, assembly 1, top view.
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Protein E6
Chains: G, H, I, J, K, L
Length: 11 amino acids
Theoretical weight: 1.39 KDa
Source organism: Human papillomavirus 16
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03126 (Residues: 148-158; Coverage: 7%)
Gene name: E6
Protein E6 in PDB entry 6hks, assembly 1, front view.
Protein E6 in PDB entry 6hks, assembly 1, side view.
Protein E6 in PDB entry 6hks, assembly 1, top view.
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