› 6hk6

X-ray diffraction
2.35Å resolution

Human RIOK2 bound to inhibitor

Released:
DOI: 10.2210/pdb6hk6/pdb
PDB entry 6hk6 coloured by chain, front view.
PDB entry 6hk6 coloured by chain, side view.
PDB entry 6hk6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human RIOK2 bound to a specific inhibitor.
Wang J, Varin T, Vieth M, Elkins JM
Open Biol 9 190037 (2019)
PMID: 30991936

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase RIO2 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 330 amino acids
Theoretical weight: 38.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BVS4 (Residues: 1-329; Coverage: 60%)
Gene names: RIO2, RIOK2
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand G8H 10 x G8H
Ligand CL 4 x CL
Ligand EDO 7 x EDO
Ligand EPE 4 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 92.01Å b: 92.86Å c: 237.65Å
α: 90° β: 99.1° γ: 90°
R-values:
R R work R free
0.216 0.215 0.235
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species.
Bailly C. (2020)
4 other articles

4 mentions without citation

Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity.
Zhang et al. (2020)
3 more