6hi1

X-ray diffraction
2.07Å resolution

PI3 Kinase Delta in complex with 3[6(morpholin4yl)pyridin2yl]phenol

Released:
Source organism: Mus musculus
Entry authors: Convery MA, Summers D, Peace S

Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A
Molecule details ›
Chain: A
Length: 940 amino acids
Theoretical weight: 107.82 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O35904 (Residues: 105-507, 509-1043; Coverage: 90%)
Gene name: Pik3cd
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 141.57Å b: 64.36Å c: 116.3Å
α: 90° β: 103.24° γ: 90°
R-values:
R R work R free
0.213 0.211 0.254
Expression system: Spodoptera frugiperda