6hhi

X-ray diffraction
2.7Å resolution

Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 30b

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAC-alpha serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 446 amino acids
Theoretical weight: 51.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31749 (Residues: 2-446; Coverage: 93%)
Gene names: AKT1, PKB, RAC
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 70.17Å b: 70.96Å c: 91.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.258
Expression system: Spodoptera frugiperda