6h7e

X-ray diffraction
2.3Å resolution

GEF regulatory domain

Released:
Source organism: Homo sapiens
Entry authors: Ferrandez Y, Cherfils J, Peurois F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rap guanine nucleotide exchange factor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 270 amino acids
Theoretical weight: 30.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: O95398 (Residues: 92-360; Coverage: 29%)
Gene names: CGEF1, EPAC, EPAC1, RAPGEF3
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Unit cell:
a: 41.698Å b: 105.617Å c: 160.556Å
α: 90° β: 90.04° γ: 90°
R-values:
R R work R free
0.197 0.195 0.237
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'