X-ray diffraction
1.88Å resolution

Crystal structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PgsA1) in complex with manganese and citrate


Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphatidylinositol phosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 24.07 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WPG7 (Residues: 1-217; Coverage: 100%)
Gene names: Rv2612c, pgsA, pgsA1
Sequence domains: CDP-alcohol phosphatidyltransferase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 68.067Å b: 77.941Å c: 100.823Å
α: 90° β: 90° γ: 90°
R R work R free
0.205 0.204 0.23
Expression system: Escherichia coli BL21(DE3)