› 6h1k

Solution NMR

The major G-quadruplex form of HIV-1 LTR

Released:
DOI: 10.2210/pdb6h1k/pdb
PDB entry 6h1k coloured by chain, ensemble of 10 models, front view.
PDB entry 6h1k coloured by chain, ensemble of 10 models, side view.
PDB entry 6h1k coloured by chain, ensemble of 10 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop.
Butovskaya E, Heddi B, Bakalar B, Richter SN, Phan AT
J Am Chem Soc 140 13654-13662 (2018)
PMID: 30299955

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-119983 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (28-MER) Chain: A
Molecule details ›
Chain: A
Length: 28 nucleotides
Theoretical weight: 8.87 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 38%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

10 review citations

Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands.
Pirota et al. (2019)
9 more

12 mentions without citation

Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acidā»Protein Interaction.
Sun et al. (2019)
11 more