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OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX

Electron Microscopy
5.6Å resolution
PDB entry 6h03 coloured by chain, front view.
PDB entry 6h03 coloured by chain, side view.
PDB entry 6h03 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 24-mer (preferred)
Entry contents: 7 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C5b6 complement complex
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Multimeric state: hetero 24-mer
Accessible surface area: 635496.53 Å2
Buried surface area: 225259.1 Å2
Dissociation area: 1,488.48 Å2
Dissociation energy (ΔGdiss): 0.86 kcal/mol
Dissociation entropy (TΔSdiss): 13.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133863

Macromolecules

Complement C5
Chain: A
Length: 1580 amino acids
Theoretical weight: 177.71 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01031 (Residues: 19-1676; Coverage: 95%)
Gene names: C5, CPAMD4
Pfam:
InterPro:
Complement C5 in PDB entry 6h03, assembly 1, front view.
Complement C5 in PDB entry 6h03, assembly 1, side view.
Complement C5 in PDB entry 6h03, assembly 1, top view.
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Complement component C8 beta chain
Chain: C
Length: 537 amino acids
Theoretical weight: 61.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07358 (Residues: 55-591; Coverage: 96%)
Gene name: C8B
Pfam:
InterPro:
Complement component C8 beta chain in PDB entry 6h03, assembly 1, front view.
Complement component C8 beta chain in PDB entry 6h03, assembly 1, side view.
Complement component C8 beta chain in PDB entry 6h03, assembly 1, top view.
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Complement component C7
Chain: D
Length: 821 amino acids
Theoretical weight: 91.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10643 (Residues: 23-843; Coverage: 100%)
Gene name: C7
Pfam:
InterPro:
Complement component C7 in PDB entry 6h03, assembly 1, front view.
Complement component C7 in PDB entry 6h03, assembly 1, side view.
Complement component C7 in PDB entry 6h03, assembly 1, top view.
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Complement component C8 gamma chain
Chain: E
Length: 182 amino acids
Theoretical weight: 20.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07360 (Residues: 21-202; Coverage: 100%)
Gene name: C8G
Pfam: Lipocalin / cytosolic fatty-acid binding protein family
InterPro:
Complement component C8 gamma chain in PDB entry 6h03, assembly 1, front view.
Complement component C8 gamma chain in PDB entry 6h03, assembly 1, side view.
Complement component C8 gamma chain in PDB entry 6h03, assembly 1, top view.
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Complement component C8 alpha chain
Chain: F
Length: 554 amino acids
Theoretical weight: 61.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07357 (Residues: 31-584; Coverage: 98%)
Gene name: C8A
Pfam:
InterPro:
Complement component C8 alpha chain in PDB entry 6h03, assembly 1, front view.
Complement component C8 alpha chain in PDB entry 6h03, assembly 1, side view.
Complement component C8 alpha chain in PDB entry 6h03, assembly 1, top view.
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Complement component C6
Chain: B
Length: 913 amino acids
Theoretical weight: 102.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P13671 (Residues: 22-934; Coverage: 100%)
Gene name: C6
Pfam:
InterPro:
Complement component C6 in PDB entry 6h03, assembly 1, front view.
Complement component C6 in PDB entry 6h03, assembly 1, side view.
Complement component C6 in PDB entry 6h03, assembly 1, top view.
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Complement component C9
Chains: G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 538 amino acids
Theoretical weight: 61.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02748 (Residues: 22-559; Coverage: 100%)
Gene name: C9
Pfam:
InterPro:
Complement component C9 in PDB entry 6h03, assembly 1, front view.
Complement component C9 in PDB entry 6h03, assembly 1, side view.
Complement component C9 in PDB entry 6h03, assembly 1, top view.
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