› 6gzu

X-ray diffraction
1.47Å resolution

Structure of Chlamydia abortus effector protein ChlaDUB

Released:
DOI: 10.2210/pdb6gzu/pdb
PDB entry 6gzu coloured by chain, front view.
PDB entry 6gzu coloured by chain, side view.
PDB entry 6gzu coloured by chain, top view.
Source organism: Chlamydia abortus
Primary publication:
A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
Pruneda JN, Bastidas RJ, Bertsoulaki E, Swatek KN, Santhanam B, Clague MJ, Valdivia RH, Urbé S, Komander D
Nat Microbiol 3 1377-1384 (2018)
PMID: 30397340

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177435 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin-like protease family profile domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 30.98 KDa
Source organism: Chlamydia abortus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5L5G1 (Residues: 108-377; Coverage: 72%)
Gene name: CAB683
Sequence domains: Ulp1 protease family, C-terminal catalytic domain

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P1
Unit cell:
a: 40.337Å b: 41.775Å c: 44.209Å
α: 94.72° β: 102.17° γ: 101.23°
R-values:
R R work R free
0.153 0.152 0.182
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Chlamydial Infection From Outside to Inside.
Gitsels et al. (2019)
12 more

1 mention without citation

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
Pruneda et al. (2018)