6gzh

X-ray diffraction
3.17Å resolution

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 9 Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 37.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50750 (Residues: 1-326; Coverage: 88%)
Gene names: CDC2L4, CDK9, TAK
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-T1 Chain: B
Molecule details ›
Chain: B
Length: 726 amino acids
Theoretical weight: 80.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60563 (Residues: 1-726; Coverage: 100%)
Gene name: CCNT1
Sequence domains: Cyclin, N-terminal domain
Structure domains: Cyclin-like

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: R3
Unit cell:
a: 171.599Å b: 171.599Å c: 97.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.171 0.257
Expression system: Spodoptera frugiperda