› 6gxy

X-ray diffraction
1.8Å resolution

Tryparedoxin from Trypanosoma brucei in complex with CFT

Released:
DOI: 10.2210/pdb6gxy/pdb
PDB 6gxy coloured by chain and viewed from the front.
PDB 6gxy coloured by chain and viewed from the side.
PDB 6gxy coloured by chain and viewed from the top.
Source organism: Trypanosoma brucei brucei
Primary publication:
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA
Angew Chem Int Ed Engl 58 3640-3644 (2019)
PMID: 30605929

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryparedoxin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 146 amino acids
Theoretical weight: 16.02 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: O77404 (Residues: 2-144; Coverage: 99%)
Sequence domains: Thioredoxin-like
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand FFN 3 x FFN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 39.63Å b: 96.009Å c: 48.276Å
α: 90° β: 96.57° γ: 90°
R-values:
R R work R free
0.168 0.165 0.212
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Label-free methods for optical in vitro characterization of protein-protein interactions.
Soltermann et al. (2021)
1 more