› 6gvl

X-ray diffraction
2.05Å resolution

Second pair of Fibronectin type III domains of integrin beta4 bound to the bullous pemphigoid antigen BP230 (BPAG1e)

Released:
DOI: 10.2210/pdb6gvl/pdb
PDB entry 6gvl coloured by chain, front view.
PDB entry 6gvl coloured by chain, side view.
PDB entry 6gvl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Integrin α6β4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes.
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
Structure 27 952-964.e6 (2019)
PMID: 31006587

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147642 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin beta-4 Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16144 (Residues: 1527-1736; Coverage: 12%)
Gene name: ITGB4
Sequence domains: Fibronectin type III domain
Dystonin Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.21 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 104.52Å b: 60.73Å c: 40.78Å
α: 90° β: 113.71° γ: 90°
R-values:
R R work R free
0.225 0.224 0.236
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

2 review citations

Chapter 22: Structural and signaling functions of integrins.
Kadry et al. (2020)
1 more