› 6gvk

X-ray diffraction
1.55Å resolution

Second pair of Fibronectin type III domains of integrin beta4 (T1663R mutant) bound to the bullous pemphigoid antigen BP230 (BPAG1e)

Released:
DOI: 10.2210/pdb6gvk/pdb
PDB 6gvk coloured by chain and viewed from the front.
PDB 6gvk coloured by chain and viewed from the side.
PDB 6gvk coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Integrin ��6��4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes.
Manso JA, Gómez-Hernández M, Carabias A, Alonso-García N, García-Rubio I, Kreft M, Sonnenberg A, de Pereda JM
Structure (2019)
PMID: 31006587

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin beta-4 Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16144 (Residues: 1527-1736; Coverage: 12%)
Gene name: ITGB4
Sequence domains: Fibronectin type III domain
Dystonin Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: C2
Unit cell:
a: 105.58Å b: 59.52Å c: 42.4Å
α: 90° β: 113.5° γ: 90°
R-values:
R R work R free
0.196 0.195 0.21
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

1 review citation

Chapter 22: Structural and signaling functions of integrins.
Kadry et al. (2020)
3 other articles