› 6gu0

X-ray diffraction
2.5Å resolution

Crystal structure of a FimH*DsG complex from E.coli F18 with bound dimannoside Man(alpha1-3)Man in space group P213

Released:
DOI: 10.2210/pdb6gu0/pdb
PDB 6gu0 coloured by chain and viewed from the front.
PDB 6gu0 coloured by chain and viewed from the side.
PDB 6gu0 coloured by chain and viewed from the top.
Source organisms:
Entry authors: Jakob RP, Sauer MM, Luber T, Canonica F, Navarra G, Ernst B, Unverzagt C, Maier T, Glockshuber R

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
FimH protein Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 29.05 KDa
Source organism: Escherichia coli F18+
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0R4I961 (Residues: 1-279; Coverage: 100%)
Gene names: ECP_4655, fimh
Sequence domains:
Structure domains: Fimbrial-type adhesion domain
FimG protein Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.42 KDa
Source organism: Escherichia coli 536
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: MMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P213
Unit cell:
a: 128.63Å b: 128.63Å c: 128.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.192
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Considerations on D-mannose Mechanism of Action and Consequent Classification of Marketed Healthcare Products.
Scaglione et al. (2021)
2 more