Structure analysis

Human AURKC INCENP complex bound to VX-680

X-ray diffraction
2.25Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero dimer
Accessible surface area: 15700 Å2
Buried surface area: 4700 Å2
Dissociation area: 1,900 Å2
Dissociation energy (ΔGdiss): 31 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -50 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 274 amino acids
Theoretical weight: 32.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UQB9 (Residues: 36-305; Coverage: 87%)
Gene names: AIE2, AIK3, AIRK3, ARK3, AURKC, STK13
Pfam: Protein kinase domain
InterPro:
CATH:

Search similar proteins

Chain: B
Length: 70 amino acids
Theoretical weight: 8.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQS7 (Residues: 835-903; Coverage: 8%)
Gene name: INCENP
InterPro:

Search similar proteins