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Human AURKC INCENP complex bound to VX-680

X-ray diffraction
2.25Å resolution
PDB entry 6gr9 coloured by chain, front view.
PDB entry 6gr9 coloured by chain, side view.
PDB entry 6gr9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aurora kinase C and Inner centromere protein
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Multimeric state: hetero dimer
Accessible surface area: 15705.09 Å2
Buried surface area: 4730.35 Å2
Dissociation area: 1,856.58 Å2
Dissociation energy (ΔGdiss): 30.4 kcal/mol
Dissociation entropy (TΔSdiss): 11.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192512

Macromolecules

Aurora kinase C
Chain: A
Length: 274 amino acids
Theoretical weight: 32.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UQB9 (Residues: 36-305; Coverage: 87%)
Gene names: AIE2, AIK3, AIRK3, ARK3, AURKC, STK13
Pfam: Protein kinase domain
InterPro:
CATH:
Aurora kinase C in PDB entry 6gr9, assembly 1, front view.
Aurora kinase C in PDB entry 6gr9, assembly 1, side view.
Aurora kinase C in PDB entry 6gr9, assembly 1, top view.
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Inner centromere protein
Chain: B
Length: 70 amino acids
Theoretical weight: 8.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQS7 (Residues: 835-903; Coverage: 8%)
Gene name: INCENP
Pfam: Inner centromere protein, ARK binding region
InterPro: Inner centromere protein, ARK-binding domain
Inner centromere protein in PDB entry 6gr9, assembly 1, front view.
Inner centromere protein in PDB entry 6gr9, assembly 1, side view.
Inner centromere protein in PDB entry 6gr9, assembly 1, top view.
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