› 6gon

X-ray diffraction
1.65Å resolution

Crystal Structure Of Sea Bream Transthyretin in complex with Perfluorooctanoic acid (PFOA). Crystallized in PEG

Released:
DOI: 10.2210/pdb6gon/pdb
PDB 6gon coloured by chain and viewed from the front.
PDB 6gon coloured by chain and viewed from the side.
PDB 6gon coloured by chain and viewed from the top.
Source organism: Sparus aurata
Primary publication:
Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals.
Zhang J, Grundström C, Brännström K, Iakovleva I, Lindberg M, Olofsson A, Andersson PL, Sauer-Eriksson AE
Environ Sci Technol 52 11865-11874 (2018)
PMID: 30226982

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 135 amino acids
Theoretical weight: 14.46 KDa
Source organism: Sparus aurata
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9PTT3 (Residues: 20-149; Coverage: 99%)
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand 8PF 2 x 8PF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 72.408Å b: 76.203Å c: 107.103Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 0.193
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors.
Guo et al. (2020)