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Crystal Structure of Glycogen synthase kinase-3 beta (GSK3B) in Complex with PIK-75

X-ray diffraction
2.6Å resolution
PDB entry 6gn1 coloured by chain, front view.
PDB entry 6gn1 coloured by chain, side view.
PDB entry 6gn1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycogen synthase kinase-3 beta
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Multimeric state: monomeric
Accessible surface area: 16785.47 Å2
Buried surface area: 89.4 Å2
Dissociation area: 44.7 Å2
Dissociation energy (ΔGdiss): 5.82 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156055
Assembly 2
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Assembly Name: Glycogen synthase kinase-3 beta
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Multimeric state: monomeric
Accessible surface area: 16626.07 Å2
Buried surface area: 98.43 Å2
Dissociation area: 49.21 Å2
Dissociation energy (ΔGdiss): 6.49 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156055

Macromolecules

Glycogen synthase kinase-3 beta
Chains: A, B
Length: 368 amino acids
Theoretical weight: 41.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49841 (Residues: 27-393; Coverage: 87%)
Gene name: GSK3B
Pfam: Protein kinase domain
InterPro:
CATH:
Glycogen synthase kinase-3 beta in PDB entry 6gn1, assembly 1, front view.
Glycogen synthase kinase-3 beta in PDB entry 6gn1, assembly 1, side view.
Glycogen synthase kinase-3 beta in PDB entry 6gn1, assembly 1, top view.
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