X-ray diffraction
2.6Å resolution

Crystal Structure of Glycogen synthase kinase-3 beta (GSK3B) in Complex with PIK-75


Function and Biology Details

Reaction catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 368 amino acids
Theoretical weight: 41.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P49841 (Residues: 27-393; Coverage: 87%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 67.63Å b: 119.5Å c: 67.48Å
α: 90° β: 102.49° γ: 90°
R R work R free
0.224 0.222 0.259
Expression system: Spodoptera frugiperda