› 6glu

X-ray diffraction
1.7Å resolution

Crystal structure of hMTH1 D120N in complex with LW14 in the presence of acetate

Released:
DOI: 10.2210/pdb6glu/pdb
PDB entry 6glu coloured by chain, front view.
PDB entry 6glu coloured by chain, side view.
PDB entry 6glu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Eberle SA, Wiedmer L, Sledz P, Caflisch A

Function and Biology Details

Reaction catalysed: 
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxidized purine nucleoside triphosphate hydrolase Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P36639 (Residues: 1-156; Coverage: 100%)
Gene names: MTH1, NUDT1
Sequence domains: NUDIX domain

Ligands and Environments

1 bound ligand:
Ligand BU8 1 x BU8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Unit cell:
a: 36.216Å b: 60.149Å c: 65.969Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.216 0.264
Expression system: Escherichia coli BL21(DE3)

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