› 6gli

X-ray diffraction
1.6Å resolution

Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the presence of acetate

Released:
DOI: 10.2210/pdb6gli/pdb
PDB 6gli coloured by chain and viewed from the front.
PDB 6gli coloured by chain and viewed from the side.
PDB 6gli coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Eberle SA, Wiedmer L, Sledz P, Caflisch A

Function and Biology Details

Reaction catalysed: 
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxidized purine nucleoside triphosphate hydrolase Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P36639 (Residues: 1-156; Coverage: 100%)
Gene names: MTH1, NUDT1
Sequence domains: NUDIX domain

Ligands and Environments

1 bound ligand:
Ligand F3E 1 x F3E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Unit cell:
a: 36.246Å b: 60.275Å c: 66.208Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.202 0.253
Expression system: Escherichia coli BL21(DE3)

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