PDBe 6gl7

Electron Microscopy
6.3Å resolution

Neurturin-GFRa2-RET extracellular complex

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neurturin Chains: A, B
Molecule details ›
Chains: A, B
Length: 102 amino acids
Theoretical weight: 11.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99748 (Residues: 96-197; Coverage: 57%)
Gene name: NRTN
Sequence domains: Transforming growth factor beta like domain
GDNF family receptor alpha-2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 426 amino acids
Theoretical weight: 47.64 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O00451 (Residues: 22-441; Coverage: 95%)
Gene names: GDNFRB, GFRA2, RETL2, TRNR2
Sequence domains: GDNF/GAS1 domain
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment Chains: E, F
Molecule details ›
Chains: E, F
Length: 613 amino acids
Theoretical weight: 68.65 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P07949 (Residues: 29-635; Coverage: 56%)
Gene names: CDHF12, CDHR16, PTC, RET, RET51
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.3Å
Relevant EMDB volumes: EMD-0026
Expression systems:
  • Escherichia coli
  • Cricetulus griseus