6gct

Electron Microscopy
3.85Å resolution

cryo-EM structure of the human neutral amino acid transporter ASCT2

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the human neutral amino acid transporter ASCT2.
Nat. Struct. Mol. Biol. 25 515-521 (2018)
PMID: 29872227
Related structures: EMD-4386

Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutral amino acid transporter B(0) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 541 amino acids
Theoretical weight: 56.64 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q15758 (Residues: 1-541; Coverage: 100%)
Gene names: ASCT2, M7V1, RDR, RDRC, SLC1A5
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.85Å
Relevant EMDB volumes: EMD-4386
Expression system: Komagataella pastoris