› 6gb6

X-ray diffraction
1.78Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135037 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
H-2 class I histocompatibility antigen, K-B alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.87 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01901 (Residues: 22-297; Coverage: 79%)
Gene names: H2-K, H2-K1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.76 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01887 (Residues: 20-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand GOL 4 x GOL
Ligand GLY 2 x GLY
Ligand LEU 2 x LEU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 66.63Å b: 82.24Å c: 89.55Å
α: 90° β: 111.29° γ: 90°
R-values:
R R work R free
0.208 0.207 0.232
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.
Dhatchinamoorthy et al. (2021)
4 more

1 mention without citation

Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Hafstrand et al. (2019)