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Ternary complex of P14 TCR with murine MHC class I H-2 Db in complex with self-antigen derived from dopamine monooxygenase.

X-ray diffraction
1.89Å resolution
PDB entry 6g9q coloured by chain, front view.
PDB entry 6g9q coloured by chain, side view.
PDB entry 6g9q coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 38257.15 Å2
Buried surface area: 10501.22 Å2
Dissociation area: 952.92 Å2
Dissociation energy (ΔGdiss): -5.43 kcal/mol
Dissociation entropy (TΔSdiss): 13.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-101335

Macromolecules

H-2 class I histocompatibility antigen, D-B alpha chain
Chain: A
Length: 276 amino acids
Theoretical weight: 32.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01899 (Residues: 25-300; Coverage: 82%)
Gene name: H2-D1
Pfam:
InterPro:
CATH:
H-2 class I histocompatibility antigen, D-B alpha chain in PDB entry 6g9q, assembly 1, front view.
H-2 class I histocompatibility antigen, D-B alpha chain in PDB entry 6g9q, assembly 1, side view.
H-2 class I histocompatibility antigen, D-B alpha chain in PDB entry 6g9q, assembly 1, top view.
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Beta-2-microglobulin
Chain: B
Length: 119 amino acids
Theoretical weight: 13.79 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01887 (Residues: 1-119; Coverage: 100%)
Gene name: B2m
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 6g9q, assembly 1, front view.
Beta-2-microglobulin in PDB entry 6g9q, assembly 1, side view.
Beta-2-microglobulin in PDB entry 6g9q, assembly 1, top view.
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Ig-like domain-containing protein
Chain: G
Length: 205 amino acids
Theoretical weight: 23.03 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0G2JF94 (Residues: 22-120; Coverage: 99%)
Gene name: Trav14-1
Pfam: Immunoglobulin V-set domain
InterPro:
CATH: Immunoglobulins
Ig-like domain-containing protein in PDB entry 6g9q, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6g9q, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6g9q, assembly 1, top view.
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T-cell receptor beta chain V region C5; T-cell receptor beta-1 chain C region
Chain: H
Length: 238 amino acids
Theoretical weight: 26.66 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04213 (Residues: 11-122; Coverage: 97%)
  • Canonical: P01852 (Residues: 1-127; Coverage: 73%)
    • nullnull
Pfam:
InterPro:
CATH: Immunoglobulins
T-cell receptor beta chain V region C5 in PDB entry 6g9q, assembly 1, front view.
T-cell receptor beta chain V region C5 in PDB entry 6g9q, assembly 1, side view.
T-cell receptor beta chain V region C5 in PDB entry 6g9q, assembly 1, top view.
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Soluble dopamine beta-hydroxylase
Chain: P
Length: 9 amino acids
Theoretical weight: 1.04 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q64237 (Residues: 557-565; Coverage: 1%)
Gene name: Dbh
Soluble dopamine beta-hydroxylase in PDB entry 6g9q, assembly 1, front view.
Soluble dopamine beta-hydroxylase in PDB entry 6g9q, assembly 1, side view.
Soluble dopamine beta-hydroxylase in PDB entry 6g9q, assembly 1, top view.
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