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Structure of MeT1 from Mycobacterium hassiacum in complex with SAM and glycerol.

X-ray diffraction
1.35Å resolution
PDB entry 6g7d coloured by chain, front view.
PDB entry 6g7d coloured by chain, side view.
PDB entry 6g7d coloured by chain, top view.
Source organism: Mycolicibacterium hassiacum DSM 44199
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MMP 1-O-methyltransferase
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Multimeric state: homo dimer
Accessible surface area: 17343.98 Å2
Buried surface area: 4614.54 Å2
Dissociation area: 1,517.55 Å2
Dissociation energy (ΔGdiss): 6.42 kcal/mol
Dissociation entropy (TΔSdiss): 12.95 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-125564

Macromolecules

MMP 1-O-methyltransferase
Chain: A
Length: 231 amino acids
Theoretical weight: 25.45 KDa
Source organism: Mycolicibacterium hassiacum DSM 44199
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: K5B7F3 (Residues: 1-218; Coverage: 100%)
Gene names: C731_4163, MHAS_04405, meT1
Pfam: Methyltransferase domain
InterPro: S-adenosyl-L-methionine-dependent methyltransferase superfamily
MMP 1-O-methyltransferase in PDB entry 6g7d, assembly 1, front view.
MMP 1-O-methyltransferase in PDB entry 6g7d, assembly 1, side view.
MMP 1-O-methyltransferase in PDB entry 6g7d, assembly 1, top view.
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