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Eg5-inhibitor complex

X-ray diffraction
1.8Å resolution
PDB entry 6g6y coloured by chain, front view.
PDB entry 6g6y coloured by chain, side view.
PDB entry 6g6y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Kinesin-like protein KIF11
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Multimeric state: monomeric
Accessible surface area: 14953.74 Å2
Buried surface area: 777.45 Å2
Dissociation area: 83.17 Å2
Dissociation energy (ΔGdiss): 12.57 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156612

Macromolecules

Kinesin-like protein KIF11
Chain: A
Length: 370 amino acids
Theoretical weight: 41.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52732 (Residues: 1-368; Coverage: 35%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Pfam: Kinesin motor domain
InterPro:
CATH: Kinesin motor domain
Kinesin-like protein KIF11 in PDB entry 6g6y, assembly 1, front view.
Kinesin-like protein KIF11 in PDB entry 6g6y, assembly 1, side view.
Kinesin-like protein KIF11 in PDB entry 6g6y, assembly 1, top view.
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