X-ray diffraction
1.35Å resolution

Human Methionine Adenosyltransferase II with SAMe and PPNP


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
S-adenosylmethionine synthase isoform type-2 Chain: A
Molecule details ›
Chain: A
Length: 395 amino acids
Theoretical weight: 43.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P31153 (Residues: 1-395; Coverage: 100%)
Gene names: AMS2, MAT2A, MATA2
Sequence domains:
Structure domains: GMP Synthetase; Chain A, domain 3

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: I222
Unit cell:
a: 67.63Å b: 94Å c: 116.69Å
α: 90° β: 90° γ: 90°
R R work R free
0.139 0.137 0.162
Expression system: Escherichia coli BL21(DE3)