› 6g4z

X-ray diffraction
2.84Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 14 Chains: A, B
Molecule details ›
Chains: A, B
Length: 349 amino acids
Theoretical weight: 38.54 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WUL6 (Residues: 329-675; Coverage: 37%)
Gene names: Map3k14, Nik
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ELW 2 x ELW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P43
Unit cell:
a: 144.83Å b: 144.83Å c: 46.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.283
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer.
Pflug et al. (2020)
5 more

2 mentions without citation

Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases.
Cheng et al. (2021)
1 more