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26S proteasome, s4 state

Source organism: Saccharomyces cerevisiae S288C
Biochemical function: protein binding
Biological process: proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular component: proteasome complex

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EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. Proteasome subunit beta type-1
  2. Proteasome subunit beta type-2
  3. Proteasome subunit beta type-3
  4. Proteasome subunit beta type-4
  5. Proteasome subunit beta type-5
  6. Proteasome subunit beta type-6
  7. Proteasome subunit beta type-7
  8. Proteasome subunit alpha type-1
  9. Proteasome subunit alpha type-2
  10. Proteasome subunit alpha type-3
  11. Proteasome subunit alpha type-4
  12. Proteasome subunit alpha type-5
  13. Proteasome subunit alpha type-6
  14. Probable proteasome subunit alpha type-7
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-1. Showing 1 copy in chain A [auth a].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-2. Showing 1 copy in chain B [auth b].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-3. Showing 1 copy in chain Q [auth C].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-4. Showing 1 copy in chain R [auth D].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-5. Showing 1 copy in chain S [auth E].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-6. Showing 1 copy in chain T [auth F].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Probable proteasome subunit alpha type-7. Showing 1 copy in chain U [auth G].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-1. Showing 1 copy in chain V [auth 1].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-2. Showing 1 copy in chain W [auth 2].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-3. Showing 1 copy in chain J [auth j].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-4. Showing 1 copy in chain K [auth k].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-5. Showing 1 copy in chain L [auth l].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-6. Showing 1 copy in chain M [auth m].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-7. Showing 1 copy in chain N [auth n].

PF10584
Domain description: Proteasome subunit A N-terminal signature
Occurring in:
  1. Proteasome subunit alpha type-1
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-3
  4. Proteasome subunit alpha type-4
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-6
  7. Probable proteasome subunit alpha type-7
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-1. Showing 1 copy in chain O [auth A].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-2. Showing 1 copy in chain P [auth B].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-3. Showing 1 copy in chain C [auth c].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-4. Showing 1 copy in chain D [auth d].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-5. Showing 1 copy in chain E [auth e].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-6. Showing 1 copy in chain F [auth f].
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Probable proteasome subunit alpha type-7. Showing 1 copy in chain G [auth g].

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome regulatory subunit 6B homolog
  5. 26S proteasome subunit RPT4
  6. 26S proteasome regulatory subunit 6A
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 7 homolog. Showing 1 copy in chain PA [auth H].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 4 homolog. Showing 1 copy in chain QA [auth I].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 6B homolog. Showing 1 copy in chain RA [auth K].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome subunit RPT4. Showing 1 copy in chain SA [auth L].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 6A. Showing 1 copy in chain TA [auth M].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 8 homolog. Showing 1 copy in chain UA [auth J].

PF01399
Domain description: PCI domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN9
  2. 26S proteasome regulatory subunit RPN5
  3. 26S proteasome regulatory subunit RPN6
  4. 26S proteasome regulatory subunit RPN7
  5. 26S proteasome regulatory subunit RPN3
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome regulatory subunit RPN3. Showing 1 copy in chain JA [auth S].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome regulatory subunit RPN5. Showing 1 copy in chain KA [auth P].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome regulatory subunit RPN6. Showing 1 copy in chain LA [auth Q].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome regulatory subunit RPN7. Showing 1 copy in chain MA [auth R].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF01399 (PCI domain) in 26S proteasome regulatory subunit RPN9. Showing 1 copy in chain OA [auth O].

PF01851
Domain description: Proteasome/cyclosome repeat
Occurring in:
  1. 26S proteasome regulatory subunit RPN2
  2. 26S proteasome regulatory subunit RPN1
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF01851 (Proteasome/cyclosome repeat) in 26S proteasome regulatory subunit RPN1. Showing 2 copies in chain HA [auth Z].
The deposited structure of PDB entry 6fvw contains 3 copies of Pfam domain PF01851 (Proteasome/cyclosome repeat) in 26S proteasome regulatory subunit RPN2. Showing 3 copies in chain IA [auth N].

PF16450
Domain description: Proteasomal ATPase OB C-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit 4 homolog
  2. 26S proteasome regulatory subunit 8 homolog
  3. 26S proteasome regulatory subunit 6B homolog
  4. 26S proteasome subunit RPT4
  5. 26S proteasome regulatory subunit 6A
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 4 homolog. Showing 1 copy in chain QA [auth I].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 6B homolog. Showing 1 copy in chain RA [auth K].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome subunit RPT4. Showing 1 copy in chain SA [auth L].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 6A. Showing 1 copy in chain TA [auth M].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF16450 (Proteasomal ATPase OB C-terminal domain) in 26S proteasome regulatory subunit 8 homolog. Showing 1 copy in chain UA [auth J].

PF17862
Domain description: AAA+ lid domain
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome subunit RPT4
  5. 26S proteasome regulatory subunit 6A
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 7 homolog. Showing 1 copy in chain PA [auth H].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 4 homolog. Showing 1 copy in chain QA [auth I].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome subunit RPT4. Showing 1 copy in chain SA [auth L].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 6A. Showing 1 copy in chain TA [auth M].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF17862 (AAA+ lid domain) in 26S proteasome regulatory subunit 8 homolog. Showing 1 copy in chain UA [auth J].

PF01398
Domain description: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Occurring in:
  1. 26S proteasome regulatory subunit RPN8
  2. Ubiquitin carboxyl-terminal hydrolase RPN11
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF01398 (JAB1/Mov34/MPN/PAD-1 ubiquitin protease) in Ubiquitin carboxyl-terminal hydrolase RPN11. Showing 1 copy in chain DA [auth V].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF01398 (JAB1/Mov34/MPN/PAD-1 ubiquitin protease) in 26S proteasome regulatory subunit RPN8. Showing 1 copy in chain NA [auth U].

PF12465
Domain description: Proteasome beta subunits C terminal
Occurring in:
  1. Proteasome subunit beta type-2
The deposited structure of PDB entry 6fvw contains 2 copies of Pfam domain PF12465 (Proteasome beta subunits C terminal) in Proteasome subunit beta type-2. Showing 1 copy in chain W [auth 2].

PF18051
Domain description: 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN1
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF18051 (26S proteasome non-ATPase regulatory subunit RPN1 C-terminal) in 26S proteasome regulatory subunit RPN1. Showing 1 copy in chain HA [auth Z].

PF17781
Domain description: RPN1 N-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN1
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF17781 (RPN1 N-terminal domain) in 26S proteasome regulatory subunit RPN1. Showing 1 copy in chain HA [auth Z].

PF05160
Domain description: DSS1/SEM1 family
Occurring in:
  1. 26S proteasome complex subunit SEM1
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF05160 (DSS1/SEM1 family) in 26S proteasome complex subunit SEM1. Showing 1 copy in chain GA [auth Y].

PF04683
Domain description: Proteasome complex subunit Rpn13, Pru domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN13
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF04683 (Proteasome complex subunit Rpn13 ubiquitin receptor) in 26S proteasome regulatory subunit RPN13. Showing 1 copy in chain FA [auth X].

PF13519
Domain description: von Willebrand factor type A domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN10
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF13519 (von Willebrand factor type A domain) in 26S proteasome regulatory subunit RPN10. Showing 1 copy in chain CA [auth W].

PF13012
Domain description: Maintenance of mitochondrial structure and function
Occurring in:
  1. 26S proteasome regulatory subunit RPN8
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF13012 (Maintenance of mitochondrial structure and function) in Ubiquitin carboxyl-terminal hydrolase RPN11. Showing 1 copy in chain DA [auth V].
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF13012 (Maintenance of mitochondrial structure and function) in 26S proteasome regulatory subunit RPN8. Showing 1 copy in chain NA [auth U].

PF10075
Domain description: CSN8/PSMD8/EIF3K family
Occurring in:
  1. 26S proteasome regulatory subunit RPN12
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF10075 (CSN8/PSMD8/EIF3K family) in 26S proteasome regulatory subunit RPN12. Showing 1 copy in chain EA [auth T].

PF08375
Domain description: Proteasome regulatory subunit C-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN3
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF08375 (Proteasome regulatory subunit C-terminal) in 26S proteasome regulatory subunit RPN3. Showing 1 copy in chain JA [auth S].

PF21154
Domain description: 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix
Occurring in:
  1. 26S proteasome regulatory subunit RPN7

PF10602
Domain description: 26S proteasome subunit RPN7
Occurring in:
  1. 26S proteasome regulatory subunit RPN7
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF10602 (26S proteasome subunit RPN7) in 26S proteasome regulatory subunit RPN7. Showing 1 copy in chain MA [auth R].

PF18503
Domain description: 26S proteasome subunit RPN6 C-terminal helix domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN6
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF18503 (26S proteasome subunit RPN6 C-terminal helix domain) in 26S proteasome regulatory subunit RPN6. Showing 1 copy in chain LA [auth Q].

PF18055
Domain description: 26S proteasome regulatory subunit RPN6 N-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN6
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF18055 (26S proteasome regulatory subunit RPN6 N-terminal domain) in 26S proteasome regulatory subunit RPN6. Showing 1 copy in chain LA [auth Q].

PF18098
Domain description: 26S proteasome regulatory subunit RPN5 C-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN5
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF18098 (26S proteasome regulatory subunit RPN5 C-terminal domain) in 26S proteasome regulatory subunit RPN5. Showing 1 copy in chain KA [auth P].

PF18261
Domain description: Rpn9 C-terminal helix
Occurring in:
  1. 26S proteasome regulatory subunit RPN9
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF18261 (Rpn9 C-terminal helix) in 26S proteasome regulatory subunit RPN9. Showing 1 copy in chain OA [auth O].

PF18004
Domain description: 26S proteasome regulatory subunit RPN2 C-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN2
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF18004 (26S proteasome regulatory subunit RPN2 C-terminal domain) in 26S proteasome regulatory subunit RPN2. Showing 1 copy in chain IA [auth N].

PF13646
Domain description: HEAT repeats
Occurring in:
  1. 26S proteasome regulatory subunit RPN2
The deposited structure of PDB entry 6fvw contains 1 copy of Pfam domain PF13646 (HEAT repeats) in 26S proteasome regulatory subunit RPN2. Showing 1 copy in chain IA [auth N].

PF21505
Domain description: 26S proteasome subunit RPN2, N-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN2

PF21236
Domain description: 26S proteasome regulatory subunit 7, OB domain
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Proteasome subunit beta type-1
  2. Proteasome subunit beta type-2
  3. Proteasome subunit beta type-3
  4. Proteasome subunit beta type-4
  5. Proteasome subunit beta type-5
  6. Proteasome subunit beta type-6
  7. Proteasome subunit beta type-7
  8. Proteasome subunit alpha type-1
  9. Proteasome subunit alpha type-2
  10. Proteasome subunit alpha type-3
  11. Proteasome subunit alpha type-4
  12. Proteasome subunit alpha type-5
  13. Proteasome subunit alpha type-6
  14. Probable proteasome subunit alpha type-7
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. Proteasome subunit beta type-1
  2. Proteasome subunit beta type-2
  3. Proteasome subunit beta type-3
  4. Proteasome subunit beta type-4
  5. Proteasome subunit beta type-5
  6. Proteasome subunit beta type-6
  7. Proteasome subunit beta type-7
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. Proteasome subunit beta type-1
  2. Proteasome subunit beta type-2
  3. Proteasome subunit beta type-3
  4. Proteasome subunit beta type-4
  5. Proteasome subunit beta type-5
  6. Proteasome subunit beta type-6
  7. Proteasome subunit beta type-7
  8. Proteasome subunit alpha type-1
  9. Proteasome subunit alpha type-2
  10. Proteasome subunit alpha type-3
  11. Proteasome subunit alpha type-4
  12. Proteasome subunit alpha type-5
  13. Proteasome subunit alpha type-6
  14. Probable proteasome subunit alpha type-7
IPR000243
Domain description: Peptidase T1A, proteasome beta-subunit
Occurring in:
  1. Proteasome subunit beta type-1
  2. Proteasome subunit beta type-2
  3. Proteasome subunit beta type-5
IPR016050
Domain description: Proteasome beta-type subunit, conserved site
Occurring in:
  1. Proteasome subunit beta type-1
  2. Proteasome subunit beta type-2
  3. Proteasome subunit beta type-3
  4. Proteasome subunit beta type-4
  5. Proteasome subunit beta type-5
  6. Proteasome subunit beta type-6
  7. Proteasome subunit beta type-7
  8. Proteasome subunit alpha type-3
  9. Proteasome subunit alpha type-4
IPR000717
Domain description: Proteasome component (PCI) domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN9
  2. 26S proteasome regulatory subunit RPN5
  3. 26S proteasome regulatory subunit RPN6
  4. 26S proteasome regulatory subunit RPN7
  5. 26S proteasome regulatory subunit RPN3
  6. 26S proteasome regulatory subunit RPN12
IPR000426
Domain description: Proteasome alpha-subunit, N-terminal domain
Occurring in:
  1. Proteasome subunit alpha type-1
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-3
  4. Proteasome subunit alpha type-4
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-6
  7. Probable proteasome subunit alpha type-7
IPR023332
Domain description: Proteasome alpha-type subunit
Occurring in:
  1. Proteasome subunit alpha type-1
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-3
  4. Proteasome subunit alpha type-4
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-6
  7. Probable proteasome subunit alpha type-7
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome regulatory subunit 6B homolog
  5. 26S proteasome subunit RPT4
  6. 26S proteasome regulatory subunit 6A
IPR003960
Domain description: ATPase, AAA-type, conserved site
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome regulatory subunit 6B homolog
  5. 26S proteasome subunit RPT4
  6. 26S proteasome regulatory subunit 6A
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome regulatory subunit 6B homolog
  5. 26S proteasome subunit RPT4
  6. 26S proteasome regulatory subunit 6A
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome regulatory subunit 6B homolog
  5. 26S proteasome subunit RPT4
  6. 26S proteasome regulatory subunit 6A
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome regulatory subunit 6B homolog
  5. 26S proteasome subunit RPT4
  6. 26S proteasome regulatory subunit 6A
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. 26S proteasome regulatory subunit RPN9
  2. 26S proteasome regulatory subunit RPN5
  3. 26S proteasome regulatory subunit RPN6
  4. 26S proteasome regulatory subunit RPN7
  5. 26S proteasome regulatory subunit RPN3
IPR002015
Domain description: Proteasome/cyclosome repeat
Occurring in:
  1. 26S proteasome regulatory subunit RPN2
  2. 26S proteasome regulatory subunit RPN1
IPR032501
Domain description: Proteasomal ATPase, second OB domain
Occurring in:
  1. 26S proteasome regulatory subunit 4 homolog
  2. 26S proteasome regulatory subunit 8 homolog
  3. 26S proteasome regulatory subunit 6B homolog
  4. 26S proteasome subunit RPT4
  5. 26S proteasome regulatory subunit 6A
IPR041569
Domain description: AAA ATPase, AAA+ lid domain
Occurring in:
  1. 26S proteasome regulatory subunit 7 homolog
  2. 26S proteasome regulatory subunit 4 homolog
  3. 26S proteasome regulatory subunit 8 homolog
  4. 26S proteasome subunit RPT4
  5. 26S proteasome regulatory subunit 6A
IPR000555
Domain description: JAB1/MPN/MOV34 metalloenzyme domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN8
  2. Ubiquitin carboxyl-terminal hydrolase RPN11
IPR016295
Domain description: Proteasome subunit beta 4
Occurring in:
  1. Proteasome subunit beta type-7
IPR007834
Domain description: DSS1/SEM1
Occurring in:
  1. 26S proteasome complex subunit SEM1
IPR044868
Domain description: Rpn13/ADRM1, Pru domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN13
IPR002035
Domain description: von Willebrand factor, type A
Occurring in:
  1. 26S proteasome regulatory subunit RPN10
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. 26S proteasome regulatory subunit RPN10
IPR024969
Domain description: EIF3F/CSN6-like, C-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN8
  2. Ubiquitin carboxyl-terminal hydrolase RPN11
IPR037518
Domain description: MPN domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN8
  2. Ubiquitin carboxyl-terminal hydrolase RPN11
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. 26S proteasome regulatory subunit RPN6
  2. 26S proteasome regulatory subunit RPN7
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. 26S proteasome regulatory subunit RPN2
  2. 26S proteasome regulatory subunit RPN1
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. 26S proteasome regulatory subunit RPN2
  2. 26S proteasome regulatory subunit RPN1
IPR033812
Domain description: Proteasome subunit alpha5
Occurring in:
  1. Proteasome subunit alpha type-5
IPR034642
Domain description: Proteasome subunit alpha6
Occurring in:
  1. Proteasome subunit alpha type-1
IPR035206
Domain description: Proteasome subunit beta 2
Occurring in:
  1. Proteasome subunit beta type-4
IPR033811
Domain description: Proteasome beta 3 subunit
Occurring in:
  1. Proteasome subunit beta type-3
IPR024689
Domain description: Proteasome beta subunit, C-terminal
Occurring in:
  1. Proteasome subunit beta type-2
IPR041433
Domain description: 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN1
IPR040892
Domain description: RPN1, N-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN1
IPR016643
Domain description: 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
Occurring in:
  1. 26S proteasome regulatory subunit RPN1
IPR006773
Domain description: Proteasomal ubiquitin receptor Rpn13/ADRM1
Occurring in:
  1. 26S proteasome regulatory subunit RPN13
IPR038633
Domain description: Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily
Occurring in:
  1. 26S proteasome regulatory subunit RPN13
IPR027040
Domain description: 26S proteasome non-ATPase regulatory subunit 4
Occurring in:
  1. 26S proteasome regulatory subunit RPN10
IPR033858
Domain description: 26S Proteasome non-ATPase regulatory subunit 7/8
Occurring in:
  1. 26S proteasome regulatory subunit RPN8
IPR033464
Domain description: CSN8/PSMD8/EIF3K
Occurring in:
  1. 26S proteasome regulatory subunit RPN12
IPR006746
Domain description: 26S proteasome non-ATPase regulatory subunit Rpn12
Occurring in:
  1. 26S proteasome regulatory subunit RPN12
IPR013586
Domain description: 26S proteasome regulatory subunit, C-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN3
IPR019734
Domain description: Tetratricopeptide repeat
Occurring in:
  1. 26S proteasome regulatory subunit RPN7
IPR045135
Domain description: 26S proteasome regulatory subunit Rpn7, N-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN7
IPR019585
Domain description: 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
Occurring in:
  1. 26S proteasome regulatory subunit RPN7
IPR040780
Domain description: 6S proteasome subunit Rpn6, C-terminal helix domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN6
IPR040773
Domain description: 26S proteasome regulatory subunit Rpn6, N-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN6
IPR040896
Domain description: 26S proteasome regulatory subunit RPN5, C-terminal domain
Occurring in:
  1. 26S proteasome regulatory subunit RPN5
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. 26S proteasome regulatory subunit RPN5
IPR040134
Domain description: 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4
Occurring in:
  1. 26S proteasome regulatory subunit RPN5
IPR040798
Domain description: Rpn9, C-terminal helix
Occurring in:
  1. 26S proteasome regulatory subunit RPN9
IPR035298
Domain description: 26S Proteasome non-ATPase regulatory subunit 13
Occurring in:
  1. 26S proteasome regulatory subunit RPN9
IPR040623
Domain description: 26S proteasome regulatory subunit RPN2, C-terminal
Occurring in:
  1. 26S proteasome regulatory subunit RPN2
IPR016642
Domain description: 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit
Occurring in:
  1. 26S proteasome regulatory subunit RPN2

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