6ftq

X-ray diffraction
2.08Å resolution

Crystal structure of human beta-ureidopropionase (beta-alanine synthase) - mutant T299C

Released:

Function and Biology Details

Reaction catalysed:
3-ureidopropanoate + H(2)O = beta-alanine + CO(2) + NH(3)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-ureidopropionase Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 43.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UBR1 (Residues: 1-384; Coverage: 100%)
Gene names: BUP1, UPB1
Sequence domains: Carbon-nitrogen hydrolase

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2221
Unit cell:
a: 86.815Å b: 104.244Å c: 102.808Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.199
Expression system: Escherichia coli BL21